TY  -  JOUR
AU  -  Viola, Giovanna
AU  -  Conte, Eutilia
AU  -  Tabeni, Patrizia
AU  -  Notti, Paola
AU  -  Locatelli, Cinzia
AU  -  Caltabiano, Sebastiano
AU  -  Galmozzi, Gustavo
AU  -  Morelli, Daniele
T1  -  Controllo delle infezioni sostenute da batteri produttori <BR>di carbapenemasi: valutazione dell’efficacia <BR>di un protocollo di sorveglianza attiva
PY  -  2014
Y1  -  2014-10-01
DO  -  10.1716/1816.19778
JO  -  GIMPIOS
JA  -  Gimpios
VL  -  4
IS  -  4
SP  -  163
EP  -  167
PB  -  Il Pensiero Scientifico Editore
SN  -  1122-407X
Y2  -  2026/05/21
UR  -  http://dx.doi.org/10.1716/1816.19778
N2  -  Introduction. Infections caused by carbapenemases-producing Enterobacteriaceae (CRE) are a growing phemomenon. This was a major clinical problem in the management of nosocomial infections for high mortality rate and for higher associated hospitalisation costs. In 2013 at the National Cancer Institute of Milan there was an outbreak of Klebsiella pneumoniae carbapenemases-producing. Methods. In order to contain the spread of these bacteria, an active surveillance program that included the rectal swabs for all patients at admission to the hospital, was introduced. Patients colonised by Enterobacteriaceae carbapenemases-producing were immediately isolated and appropriate infection control measures were applied. Isolation of bacteria carbapenemases-producing from rectal swabs were performed using chromogenic plates "Brilliance CRE agar for screening of carbapenem - resistant". The strains were processed with the instrument Phoenix (Becton Dickinson). The modified Hodge Test and DD-Synergy Test with Boronic acid were used as phenotypic confirmation. Data related to infection and colonisation by Klebsiella pneumoniae carbapenemases-producing in patients hospitalised at our Institution from January 2013 to September 2014 were processed. Results. During 2013, 35 strains were collected from various biological samples. In 13 patients, we isolated the organism in the blood and 5 of the patients (38.5%) died due to septic shock. In the months that followed the introduction of the rectal swabs of all Patients admitted to the surveillance programme, the number of Klebsiella pneumoniae carbapenemases-producing infections was decreased. Also the number of colonised patients has decreased over time. Discussion. Our experience shows that in Health Care, early control and surveillance of infections and colonisation patients by Klebsiella pneumoniae carbapenemases-producing, can strongly eradicate or contain the spread of these organisms.
ER  -